AMA Journal of Ethics®

Illuminating the art of medicine

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AMA Journal of Ethics®

Illuminating the art of medicine

AMA Journal of Ethics. July 2016, Volume 18, Number 7: 681-690.
doi: 10.1001/journalofethics.2016.18.07.ecas3-1607.

Ethics Case

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Changing Donor Funding and the Challenges of Integrated HIV Treatment

The shift to general health systems strengthening could have harmful consequences for patients who receive care through disease-specific programs.

Commentary by Nicoli Nattrass, DPhil, MSc, MA, Rebecca Hodes, DPhil, and Lucie Cluver, DPhil

Abstract

Donor financing for HIV prevention and treatment has shifted from supporting disease-specific (“vertical”) programs to health systems strengthening (“horizontal”) programs intended to integrate all aspects of care. We examine the consequences of shifting resources from three perspectives: first, through a broad analysis of the changing policy context of health care financing; second, through an account of changing priorities for HIV treatment in South Africa; and third, through a description of some clinical consequences that the authors observed in a research study examining adherence to antiretroviral therapy (ART) and sexual health among adolescents. We note that AIDS responses are neither completely vertical nor horizontal but rather increasingly diagonal, as disease-specific protocols operate alongside integrated supply chain management, human resource development, and preventive screening. We conclude that health care programs are better conceived of as networks of policies requiring different degrees of integration into communities.

Case

You are an infectious disease physician from the United States leading a partnership with a group of local clinics in Southern Africa in providing antiretroviral medications as well as HIV testing and education. Recently, though, there have been discussions among donors about reallocating money to build primary care systems rather than directing resources to respond to specific diseases, such as HIV. Some donors have suggested that building health care infrastructure might be more cost effective and save more lives in the long run and that it is unethical to favor responding to one disease over another. A drawback of the infrastructure-building approach is also acknowledged in these discussions: thousands of people with HIV will lose access to antiretroviral medications within the next few months if resources are shifted. You consider that some increase in mortality might be acceptable if benefits are conferred upon a larger number of patients, but you also worry that some of the patients you’ve been treating will be directly affected by these policy changes. How should you and other physicians working in this context balance ethical obligations to their individual patients and to donors who must approach health systems macroscopically? How should these tensions be managed effectively?

Commentary

Financing for health care is in perpetual flux. Physicians and nurses working in resource-constrained contexts might develop their own tactics to optimize treatment and care for their patients. But how should health care workers respond when changing priorities of donors and developmental agencies threaten to disrupt supplies of essential medicines for chronic diseases like AIDS? Should they counsel lifelong adherence to antiretroviral therapy (ART) as a prerequisite for survival, even if ART might no longer be available? This is a core question posed by the case. But, in stating that “thousands of people with HIV will lose access to antiretroviral medications within the next few months if resources are shifted,” the hypothetical case constitutes a clear violation of global, national, and bilateral commitments to sustaining HIV treatment for patients for whom treatment is already initiated [1-4].

Our focus here is on the more subtle ways in which changing donor priorities can impact health resource allocation and clinical care provision. We examine some of the consequences of changing resources from three perspectives: first, through an analysis of developments in the political economy of health care financing; second, through an account of changing priorities for HIV treatment in South Africa; and third, through a description of clinical consequences. Our perspective on the ethical dilemmas that health care workers might confront in the aftermath of shifts in donor funding for health care is based on our research on the socioeconomic and experiential aspects of HIV treatment in South Africa; we run the largest known longitudinal, community-based study on medicines-taking and sexual health among HIV-positive adolescents [5-8]. And with an HIV-prevalence rate of 18.9 percent among adults aged 15 to 49 [9] and approximately 5.9 million South Africans who are HIV-positive, South Africa has the world’s largest HIV epidemic [2].

The Changing Policy Context of Donor Funding for ART Programs

Donor financing for HIV prevention and treatment has shifted from supporting disease-specific (“vertical”) programs to health systems strengthening (“horizontal”) programs intended to integrate disease-specific care. Since the World Health Organization (WHO) Declaration of Alma-Ata of 1978 [10], there has been a strong current in public health in favor of primary health care and on general health systems as the most efficient way of delivering health care to the greatest number of people. The contemporary push towards horizontal health systems support and primary health care as an alternative to vertical AIDS funding is sometimes framed as a revival of Alma Ata. The horizontal restructuring of health care services, however, does not necessarily result in treatment disruptions for HIV-positive patients. Nevertheless, if health care services are not integrated cautiously—in response to the needs of local patients, clinicians, and services—this could be detrimental at the individual and systems levels [11, 12].

The AIDS epidemic galvanized one of the most effective health activist efforts of the twentieth century. This movement emerged among gay men in the metropolitan centers of the United States and Europe in the mid- to late-1980s and grew into a broader international response among health care activists. Key scientific advancements followed, particularly the development of the first ART in 1987 and then generic formulations in the 1990s [13]. Nevertheless, the exorbitant cost of ART was an impediment to treatment delivery in resource-poor countries, inspiring new forms of social mobilization and policy changes in line with global commitments to providing universal access to ART [14].

The ethical core of the international AIDS response was the demand for ART as a human right [11] rather than as a good available only for citizens in well-resourced countries. In the late 1990s and early 2000s, influential US officials, including a former head of the United States Agency for International Development (USAID), opposed the public provision of ART in the global South, citing patent laws, the high costs of branded medicines, and the perceived inability of patients in resource-poor areas to adhere adequately [15]. Through advocacy and evidence, however, this stance began to change. In 2003, President George W. Bush pledged $15 billion to AIDS through the President’s Emergency Plan for AIDS Relief (PEPFAR) [16]. In 2005, the Group of Eight (G8)—France, Germany, Italy, the UK, Japan, the US, Canada, and Russia—promised Africa $25 billion to provide universal HIV treatment by 2010 [17]. Humanitarian agencies, such as the Joint United Nations Programme on HIV/AIDS (UNAIDS), and philanthropic agencies, such as the Global Fund to Fight AIDS, Tuberculosis and Malaria, started investing in the global rollout of ART. Partnerships among donor agencies, government health departments, local health care workers, and nongovernmental organizations (NGOs) flourished [18, 19]. Investment in ART was motivated not only by the development of cheap generic formulations of ART, but also by the international focus on HIV as an issue of global security [4, 12].

The unprecedented international response to HIV/AIDS helped fund national ART programs in developing countries. Although funding increased globally for health initiatives from the mid-2000s, donor funding for AIDS rose faster than other categories of health spending [20]. Rather than “crowding out” other health spending, the international AIDS response helped mobilize additional resources for health systems [12]. Because of their explicit commitment to funding ART, national health departments in sub-Saharan Africa, in collaboration with donor agencies such as the Global Fund and PEPFAR, could use HIV-specific funds to strengthen health care systems more broadly [16, 21-22].

The vigorous AIDS response supported patients and health care workers, strengthened distribution networks for medical services, pumped essential resources into pharmacies and diagnostics, and helped reduce the rate of new HIV infections and AIDS-related mortality and morbidity [12, 21, 23-25]. These initiatives also strengthened health systems more broadly [16, 21-22].

After the financial crisis of 2008, however, there was growing concern among physicians and program leaders that funds dedicated for ART would be reapportioned, leaving patients in the lurch. At the XVIII International AIDS Conference held in Vienna in 2010, Ugandan physician Peter Mugyenyi described how past arguments concerning the cost effectiveness of ART had resurfaced:

Once again, we are facing some of those prospects which we faced in the mid-1990s. We are beginning to hear this language once more, that universal access is too expensive and that we can’t do it…. We need commitment from our governments, from the international community, and from the leadership of rich countries. The emergency has not gone away. We have a financial crunch. AIDS, more than anything else, requires that resources be increased so that we can continue to solve the century’s most devastating health problem [26].

Without access to ART and support in adhering to it, patients face the threat of return to a pre-HIV treatment era. Not only would this violate their human right to health care [27], it also would place momentous strain on health care systems, as wards would again be filled with HIV-positive patients with advanced opportunistic infections and precarious prospects for recovery and survival.

Changing AIDS Policy in South Africa

Political responses to HIV in South Africa over the last decade have been the focus of much public attention [28, 29]. The AIDS denialism of President Thabo Mbeki and Health Minister Manto Tshabalala-Msimang is one of the most contentious issues to have arisen during the post-apartheid era [30]. The protracted battle for public ART access was waged between South Africa’s HIV activist movement and political officials during the late 1990s and early 2000s. However, this did not stop health care workers and bilateral partners from piloting programs to treat and manage HIV in keeping with advancing evidence [18]. Donor-funded projects helped support ART programs from the early 2000s, but it was only after 2005 that ART began to become accessible beyond these individual programs [28]. As donors and bilateral agencies such as UNAIDS, the World Health Organization, the Global Fund, and PEPFAR honed their focus on ART provision, the scope of South Africa’s HIV treatment program expanded rapidly. By September 2005, 85,000 people had initiated ART in South Africa’s public health sector [31]. By 2015, South Africa had the world’s largest ART program, with 2.6 million people on HIV treatment [32].

South Africa’s public provision of ART is the result of a vast mobilization of patients, health care workers, government officials, NGOs, bilateral agencies, and international donors, who have worked together to provide and sustain public access to HIV treatment [19]. To help shoulder the weight of AIDS clinical care, cohorts of community health care workers were employed and clinics began to promote HIV treatment [17]. Mobile HIV testing sites also offered blood sugar testing and contraceptive counseling. Clinic infrastructure was improved, both to host HIV testing and treatment programs and to better capture epidemiological and clinical data [19, 33].

South Africa is one of the states whose national HIV treatment programs helped strengthen health systems and save lives. South Africans on ART can now expect relatively normal life spans [34]. But, as we suggest below, this success is vulnerable to changes in donors’ and governments’ health care priorities and practices [20, 34].

Donor Decisions, Clinical Consequences

The effects of changing donor commitments and of governmental reapportioning of resources are evident in our research with HIV-positive adolescents in the Eastern Cape, one of South Africa’s poorest provinces with among the highest rates of infant mortality. Many of the adolescents in this research (aged 10 to 19) were born during the era of President Mbeki’s AIDS denialism, prior to the establishment of a national program to prevent mother-to-child transmission of HIV. Thus, their mothers could not access medicines to reduce perinatal HIV transmission.

Our research, constituting over 1,000 hours of observation at South African public health care facilities over the course of three years, has shown the importance of carefully considering, as the case scenario suggests, the chasm that can develop between neatly defined donor objectives and their real-world implementation.

This chasm can be seen in one of the health care facilities specializing in the treatment of multidrug-resistant tuberculosis (TB) in which we worked and where many patients are co-infected with HIV and TB. Prior to the drive to integrate HIV services with general care, a dedicated HIV clinic and patient “folder depot” served these patients. To solve the problem of relevant clinical information being kept in separate parts of the clinic, which could potentially add hours to a patient’s waiting time, the “folder depot” enabled adolescent patients to fetch their folders from a consolidated data source, see a nurse for a medication refill, and complete their clinical visit within three to four hours.

In the second half of 2015, however, the policy imperative to try to integrate services according to the model of a streamlined, “horizontal” service disrupted the clinic’s own model for optimizing the treatment and management of HIV-positive patients. This model had been developed slowly, by a team of nurses, pharmacists, data capturers and—critically—expert patients who received their own ART at the clinic. The result of this change was not necessarily a shorter waiting time for patients in general, but a longer waiting time for patients on ART, who were combined with patients receiving general services. For adolescents participating in our research who needed ART, this meant that they had to arrive early in the morning and be prepared to wait all day. They reported missing days of school (for which they could be punished) and were further at risk for stigmatization if their HIV status became known to teachers. For the patients’ caregivers, this could mean the loss of a day’s wages or make it more difficult to maintain a regular job, threatening a reduction in family resources and worsening poverty and food insecurity. For the families reliant on this health care facility, horizontal services integration has not reduced HIV stigma or improved equality; instead, it has exacerbated the challenges of living with HIV and AIDS.

Conclusion

Although the provision of ART in developing countries like South Africa was facilitated by donor support, retreat of donors from their commitments to funding ART programs could portend harmful consequences for patients, as is evident in our study of HIV-positive adolescents in South Africa’s Eastern Cape. The shift in health care spending from disease-specific interventions to the more general provision of services is being justified with reference to the equity considerations of the Declaration of Alma-Ata [10]. Yet we have seen that AIDS responses are neither completely vertical nor horizontal but, rather, increasingly diagonal, as disease-specific protocols operate alongside integrated supply chain management, human resource development, and preventive screening [35]. In the decades after Alma-Ata, research has shown that health care programs are better conceived as networks of policies requiring different degrees of integration into communities [36]. The success of integrated health care, especially in countries with high HIV-prevalence, depends on the sustained provision of HIV treatment [37]. A strictly horizontal approach is blind to the challenges of managing ART programs and to the broader public benefits (fewer new HIV infections, lower morbidity and mortality) of a strong ART program. A weak ART program will harm patients and risk a resurgent AIDS epidemic. In South Africa, political obstructions to ART have subsided in the wake of successive government commitments and ambitious plans for the provision of HIV testing and treatment programs. The difficulties of sustaining ART provision, and of developing patient-led strategies to support adherence to ART, are the next challenges that frontline health care workers will confront.



References

  1. World Health Organization. Global Update on HIV Treatment 2013: Results, Impact and Opportunities. Geneva, Switzerland: World Health Organization; 2013. http://www.unaids.org/sites/default/files/media_asset/20130630_
    treatment_report_en_0.pdf. Accessed April 27, 2016.
  2. AVERT. HIV and AIDS in South Africa. http://www.avert.org/professionals/hiv-around-world/sub-saharan-africa/south-africa. Accessed April 27, 2016.
  3. Joint United Nations Programme on HIV/AIDS. The Gap Report. Geneva, Switzerland: Joint United Nations Programme on HIV/AIDS; 2014. http://www.unaids.org/sites/default/files/media_asset/UNAIDS_Gap_
    report_en.pdf. Accessed April 27, 2016.
  4. Nattrass NJ. The (political) economics of antiretroviral treatment in developing countries. Trends Microbiol. 2008;16(12):574-579.
  5. Cluver LD, Hodes RJ, Toska E, et al. “HIV is like a tsotsi. ARVs are your guns”: associations between HIV-disclosure and adherence to antiretroviral treatment among adolescents in South Africa. AIDS. 2015;29(suppl 1):S57-S65.
  6. Toska E, Cluver LD, Hodes R, Kidia KK. Sex and secrecy: how HIV-status disclosure affects safe sex among HIV-positive adolescents. AIDS Care. 2015;27(suppl 1):47-58.
  7. Hodes R. The culture of illegal abortion in South Africa. J South Afr Stud. 2016;42(1):79-93.
  8. Cluver LD, Hodes RJ, Sherr L, et al. Social protection: potential for improving outcomes among adolescents. J Int AIDS Soc. 2015;18(suppl 6):20260. http://www.jiasociety.org/index.php/jias/article/view/20260/html. Accessed May 11, 2016.
  9. UNAIDS. South Africa: HIV and AIDS estimates (2014). http://www.unaids.org/en/regionscountries/countries/southafrica. Accessed June 2, 2016.
  10. World Health Organization. Declaration of Alma-Ata. http://www.who.int/publications/almaata_declaration_en.pdf. Issued September 1978. Accessed May 11, 2016.
  11. Mann JM. Human rights and AIDS: the future of the pandemic. In: Schenker II, Sabar-Friedman G, Sy FS, eds. AIDS Education: Interventions in Multi-Cultural Societies. New York, NY: Plenum Press; 1996:1-8.
  12. Nattrass N, Gonsalves G. AIDS funds: undervalued. Science. 2010;330(6001):174-175.
  13. Avert. History of HIV and AIDS overview. http://www.avert.org/professionals/history-hiv-aids/overview. Accessed June 2, 2016.
  14. Farmer P, Léandre F, Mukherjee JS, et al. Community-based approaches to HIV treatment in resource-poor settings. Lancet. 2001;358(9279):404-409.
  15. Herbert B. In America; refusing to save Africans. New York Times. June 11, 2001. http://www.nytimes.com/2001/06/11/opinion/in-america-refusing-to-save-africans.html. Accessed April 27, 2016.
  16. Piot P. AIDS Between Science and Politics. New York, NY: Columbia University Press; 2015.
  17. G8’s promises to Africa. Lancet. 2007;369(9576):1833.
  18. Hodes R, Naimak TH. Piloting antiretroviral treatment in South Africa: the role of partnerships in the Western Cape’s provincial roll-out. Afr J AIDS Res. 2011;10(4):415-425.
  19. Grimsrud A, Lesosky M, Kalombo C, Bekker LG, Myer L. Implementation and operational research: community-based adherence clubs for the management of stable antiretroviral therapy patients in Cape Town, South Africa: a cohort study. J Acquir Immune Defic Syndr. 2016;71(1):e16-e23.
  20. Nattrass N. Millennium Development Goal 6: AIDS and the international health agenda. J Human Dev Capabil. 2014;15(2-3):232-246.
  21. The Global Fund to Fight AIDS, Tuberculosis and Malaria. Scaling up for Impact: Results Report. Geneva, Switzerland: The Global Fund to Fight AIDS, Tuberculosis and Malaria; 2009. http://files.givewell.org/files/DWDA%202009/GFATM/ProgressReport2008
    _en.pdf. Accessed June 2, 2016.
  22. Yu D, Souteyrand Y, Banda MA, Kaufman J, Perriëns JH. Investment in HIV/AIDS programs: does it help strengthen health systems in developing countries? Global Health. 2008;4:8. http://globalizationandhealth.biomedcentral.com/articles/10.1186/1744-8603-4-8. Accessed May 11, 2016.
  23. Dorrington R, Bradshaw D, Laubscher R. Rapid Mortality Surveillance Report 2012. Cape Town, South Africa: South African Medical Research Council; 2013. http://www.mrc.ac.za/bod/RapidMortalitySurveillanceReport2012.pdf. Accessed April 27, 2016.
  24. Bekker LG, Venter F, Cohen K, et al. Provision of antiretroviral therapy in South Africa: the nuts and bolts. Antivir Ther. 2014;19(suppl 3):105-116.
  25. Bor J, Herbst AJ, Newell ML, Bärnighausen T. Increases in adult life expectancy in rural South Africa: valuing the scale-up of HIV treatment. Science. 2013;339(6122):961-965.
  26. Hodes R. Universal access to HIV treatment threatened by failure of will. NAM Aidsmap. July 20, 2010. http://www.aidsmap.com/Universal-access-to-HIV-treatment-threatened-by-failure-of-will/page/1493647. Accessed April 27, 2016.
  27. World Health Organization. Fact sheet: the right to health. http://www.who.int/mediacentre/factsheets/fs323_en.pdf. Published August 2007. Accessed April 28, 2016.
  28. Nattrass N. Mortal Combat: AIDS Denialism and the Struggle for Antiretrovirals in South Africa. Scottsville, South Africa: University of KwaZulu-Natal Press; 2007.
  29. Hodes R. Broadcasting the Pandemic: A History of HIV on South African Television. Cape Town, South Africa: HSRC Press; 2014.
  30. Schneider H. On the fault-line: the politics of AIDS policy in contemporary South Africa. Afr Stud. 2002;61(1):145-167.
  31. Simelela NP, Venter WD. A brief history of South Africa’s response to AIDS. S Afr Med J. 2014;104(3)(suppl 1):249-251.
  32. Joint United Nations Programme on HIV/AIDS. Treatment 2015. Geneva, Switzerland: Joint United Nations Programme on HIV/AIDS; 2012. http://www.unaids.org/sites/default/files/media_asset/JC2484_treatment-2015_en_1.pdf. Accessed April 27, 2016.
  33. Johnson LF, Mossong J, Dorrington RE, et al; International Epidemiologic Databases to Evaluate AIDS Southern Africa Collaboration. Life expectancies of South African adults starting antiretroviral treatment: collaborative analysis of cohort studies. PLoS Med. 2013;10(4):e1001418. http://journals.plos.org/plosmedicine/article?id=10.1371/journal.pmed.1001418. Accessed May 11, 2016.
  34. Kowalski S. US government leading backlash against AIDS funding. Open Society Foundations. April 23, 2010. https://www.opensocietyfoundations.org/voices/us-government-leading-backlash-against-aids-funding. Accessed April 27, 2016.
  35. Samb B, Evans T, Dybul M; World Health Organisation Maximizing Positive Synergies Collaborative Group. An Assessment of interactions between global health initiatives and country health systems. Lancet. 2009;373(9681):2137-2169.
  36. Mills A. Mass campaigns versus general health services: what have we learnt in 40 years about vertical versus horizontal approaches? Bull World Health Organ. 2005;83(4):315-316.
  37. Piot P, Kazatchkine M, Dybul M, Lob-Levyt J. AIDS: lessons learnt and myths dispelled. Lancet. 2009;374(9685):260-263.

Nicoli Nattrass, DPhil, MSc, MA, is a professor in the Centre for Social Science Research and the School of Economics at the University of Cape Town in South Africa. She has written extensively on the political economy of South Africa and access to antiretroviral therapy.

Rebecca Hodes, DPhil, is director of the AIDS and Society Research Unit in the Centre for Social Science Research at the University of Cape Town in South Africa. Rebecca is co-principal investigator of the Mzantsi Wakho study about adolescents’ adherence to antiretroviral therapy and sexual health in the Eastern Cape.

Lucie Cluver, DPhil, is a professor of child and family social work at the University of Oxford in England and in the Department of Psychiatry and Mental Health at the University of Cape Town in South Africa. Lucie is co-primary investigator of the Mzantsi Wakho study of adolescents on antiretroviral therapy in the Eastern Cape.

Acknowledgements

We acknowledge and thank all research participants in the Mzantsi Wakho study, particularly adolescents, families, and health care providers. The study is guided and supported by the Pediatric AIDS Management Programme of the Eastern Cape provincial Department of Health and by 53 health facilities in the Amathole district, Eastern Cape, South Africa. We thank Gerry Boon, Luntu Galo, and Nompulelelo Zungu for their mentorship and oversight, and Craig Carty, Nontuthuzelo Bungane, Mavis Nobuhle, Elona Toska, and Beth Vale for their partnership. Particular thanks are due to Abraar Karan and Melissa Kuriloff.

How Has the Global Fund Affected the Fight against AIDS, Tuberculosis and Malaria?, December 2006

Medical Volunteerism in Africa: An Historical Sketch, December 2006

Promoting Health as a Human Right in the Post-ACA United States, October 2015

Will Risk Compensation Accompany Pre-Exposure Prophylaxis for HIV?, November 2014

Why US Health Care Should Think Globally, July 2016

The people and events in this case are fictional. Resemblance to real events or to names of people, living or dead, is entirely coincidental. The viewpoints expressed in this article are those of the author(s) and do not necessarily reflect the views and policies of the AMA.