Despite legislative attention from Congress in the 1980s, diagnostic research into rare diseases is not lucrative enough to garner sufficient private funding. 

This response to an article suggests that the authors erred in committing the errors they critique.

Finding an accurate diagnosis can be a long and complex process.

The UDN seeks to advance diagnostic science and to facilitate accurate diagnoses of individual patient-participants’ “medical mysteries.”

Patients whose conditions are undiagnosed face stress and limited, delayed access to interventions that address their specific needs.

UDN research is complex and involves many variables, and some patient-subjects think that having enrolled in a UDN protocol was not worthwhile.

A national consortium of clinicians and researchers hope to accurately diagnose patients with rare diseases.

Medicaid provides health insurance for nearly half of children in the United States, but this coverage has been unstable because of redetermination requirements.

Optimal strategies for structural drivers of health screening, referrals, and interventions remain unclear.

Early childhood adversity and trauma can influence a person’s health throughout their lifespan and contribute to chronic disease and early death.