A history of device oversight by the US Food and Drug Administration traces regulatory changes in response to injuries caused by Dalkon Shield intrauterine devices.
AMA J Ethics. 2021;23(9):E712-720. doi:
10.1001/amajethics.2021.712.
Diethylstilbestrol (DES) was widely used in the 1940s to 1960s to prevent pregnancy loss but was later found to be associated with adverse health effects in exposed offspring, underscoring the need for careful evaluation of new therapies.
AMA J Ethics. 2015;17(9):865-870. doi:
10.1001/journalofethics.2015.17.9.mhst1-1509.
In the past, forced sterilizations violated the autonomy of vulnerable women. Today, measures intended to protect such women from the abuses of the past may in fact hamper their autonomy in a different way.
Conflicts between federal and state laws governing marijuana, lack of evidence about its efficacy as a treatment, and physicians' inability to predict or control dosage would all be aided by reclassification of the drug that would let clinical research go forward.
Though there are channels through which terminally ill patients can access some experimental drugs that have not yet received FDA approval for marketing to the public, in general those drugs must already be proven safe and effective.
The most controversial component of the ACA has arguably been the mandate that group health plans cover contraception costs, which has elicited backlash from religious and conservative groups who believe it violates certain employers' religious freedoms.
There are numerous state and federal laws designed to protect against misuse and diversion of prescription drugs that apply to patients' behavior, physicians' prescribing practices, and dispensing.