Diethylstilbestrol (DES) was widely used in the 1940s to 1960s to prevent pregnancy loss but was later found to be associated with adverse health effects in exposed offspring, underscoring the need for careful evaluation of new therapies.
AMA J Ethics. 2015;17(9):865-870. doi:
10.1001/journalofethics.2015.17.9.mhst1-1509.