This process of developing EBM-based guidelines and applying them to clinical care highlights the tension between generating unbiased knowledge based on statistical aggregation and the application of this information to individual patients.
Elderly persons should not be excluded from participation in clinical trials for cardiovascular drugs since that population comprises the largest number of patients with cardiovascular disease.
The FDA's decision to put a black-box warning on antidepressant labels may be misleading because it implies that antidepressants have definitely been found to increase suicidality in adolescents, when in fact there is merely a lack of clear evidence about their safety.
An interview with Allan Ramsay, one of the five appointed members of the Green Mountain Care Board, which oversees the development of Vermont’s single-payer health care system.
Believing that unnecessary use of resources is a significant contributor to rising health care costs, the ABIM Foundation launched the Choosing Wisely campaign, in which physicians and patients work together to develop treatment plans that are effective for the patient but are also efficient and promote the sustainable use of limited resources.
CBP researchers are challenged to think strategically about ways to convey their accomplishments and educate their non-CBPR peers about the nature of their research, processes not required of traditional researchers.
There is a market for direct-to-consumer genetic testing and a need for better consumer information and more regulation of tests and testing laboratories.
Medical stewardship is a way of describing a relatively new obligation to maximize health care resources. A professionwide conversation about its meaning and value is needed.
Specific advocate guidelines are needed for the protection of children in state custody who are potential research subjects in trials that would expose them to greater-than-minimal risk but also hold the prospect of direct benefit.