Drs Katrina Bramstedt and Ana Iltis discuss the development of QoL assessment tools to help patient-subjects considering reconstructive transplantation.

Facial transplantation must establish approaches to assessing QoL in candidates and recipients that use meaningful outcomes.

Despite drawbacks of immunosuppression and surgery, vascularized composite allotransplants can enhance lives of patients who meet candidacy criteria and are well supported.

Recent advances in UTx suggest it is on a trajectory toward becoming an accepted clinical practice to treat absolute uterine factor infertility.

Success depends on strong support, rehabilitation, adherence, and social integration.

Clarifying both patients’ and professionals’ values fosters good clinical decision making, particularly in situations of uncertainty.

Prognostic uncertainty about risk creates demand for ongoing communication and facilitated reflection about goals and values.

Selected ideas in C. Donald Combs and P. Ford Combs’ article, “Emerging Roles of Virtual Patients in the Age of AI,” are further considered.

Decision aids could help clinicians know when to request ethics consultation or re-evaluate blood product usage in a specific patient care situation.

Four MDGs directly concern public health, and public health schools should be involved in meeting them.