Therapeutic misconception—a false belief that individuals will benefit from participating in research—can bias informed consent. Ethics consultants can help by engaging participants’ and researchers’ understandings of risks and benefits and by asking good questions about the influences of researchers’ enthusiasm.

Clinician-researchers deeply invested in data gathering are still obliged to respect a patient-subject’s right to stop being in research.

Shared decision making in research informed consent conversations is complex due to diverse and potentially divergent interests of investigators and patient-subjects.

Drs Katrina Bramstedt and Ana Iltis discuss the development of QoL assessment tools to help patient-subjects considering reconstructive transplantation.

Legacy patients are so-called because their opioid use behaviors express past, aggressive opioid prescribing by a clinician. Managing their pain and dependence justly is ethically complex.

A 3-step analgesic ladder was introduced in 1986 and needs change. Surgical interventions could reduce opioid use and motivate expansion of current pain management approaches.

Until the mid-20th century, birth in the United States for Latinx Indigenous peoples was an ancestral ceremony guided by midwives and traditional healers.

Helping patients mitigate their risk of chronic disease is key, but dietary supplements are risky.

Children with micronutrient deficiency might need supplementation, sometimes in irregularly high doses.

Consumption of over-the-counter vitamins, minerals, and herbals is widespread, but clinicians lack critical information about their use.