Specific advocate guidelines are needed for the protection of children in state custody who are potential research subjects in trials that would expose them to greater-than-minimal risk but also hold the prospect of direct benefit.
Physicians’ ethical obligations to disclose conflicts of interest to patients and to obtain their informed consent for treatment are particularly critical when proposed treatments are experimental.
Chris Feudtner, MD, PhD, MPH, David Munson, MD, and Wynne Morrison, MD
The way that we choose how to frame the conversation with parents about halting or continuing such therapy for their children who will not recover has special importance in medicine and in society.
Raphael P. Viscidi, MD and Keerti V. Shah, MD, DrPH
The arguments for mandatory vaccination with human papillomavirus vaccine differs from the justification for mandatory use of vaccines that protect against more easily transmitted diseases.
Article explains the right granted to state public health agencies by the Supreme Court in Jacobson v Massachusetts to mandate vaccination in the presence of actual or threatened danger to the health of its residents from infectious disease.
Clinical trials for the blood substitute PolyHeme exposed the possibility for ambiguous interpretation of the FDA’s waiver of informed consent for emergency research.
Parents’ right to choose the culture of their children and a child’s right to an open future outweigh the right of the Deaf to perpetuate their culture by disallowing government funding of cochlear implant research to restore hearing.
The ongoing anthrax vaccination case, Doe v Rumsfeld, tests whether the military can require participation in and punish refusal of a vaccination program while waiving informed consent.
In “Ethics of International Research: What Does Responsiveness Mean?” Christine Grady explains how developing countries are vulnerable to exploitation by researchers and explores what “responsiveness” to the needs of those populations might entail.