Chromosomal microarray analysis reveals many gene variants of unknown significance. The uncertainty about these variants—might they be deleterious or are they benign?—complicates genetic counseling.
Laurel J. Lyckholm, MD and Arwa K. Aburizik, MD, MS
Decision-making capacity can be preserved in patients with mental illness and should be formally assessed in the context of their values and past decisions.
AMA J Ethics. 2017; 19(5):444-453. doi:
10.1001/journalofethics.2017.19.5.ecas4-1705.
LaPrincess C. Brewer, MD, MPH and Lisa A. Cooper, MD, MPH
Stressful life experience associated with racial and ethnic discrimination can have detrimental effects on the coronary and cardiovascular health of people in historically marginalized groups.
Nonmaleficence must not be sacrificed in the name of the patient’s autonomy, but there is no need to undertake needlessly invasive treatments for a small boost in protection against cancer recurrence if the patient does not wish to do so.
Ruth M. Farrell, MD, MA, Holly Pederson, MD, and Shilpa Padia, MD
Though they claim to, direct-to-consumer genetic tests may not correctly identify an individual's ancestral background, and thus may overstate or understate one's risk for heritable disease.
Decision-making capacity can be preserved in patients with mental illness and should be formally assessed in the context of their values and past decisions.
AMA J Ethics. 2017; 19(5):416-425. doi:
10.1001/journalofethics.2017.19.5.ecas1-1705.