Prognostic uncertainty about risk creates demand for ongoing communication and facilitated reflection about goals and values.

Clinician-researchers deeply invested in data gathering are still obliged to respect a patient-subject’s right to stop being in research.

Improving candidate evaluation and informed consent is key to motivating authenticity, not just voluntariness.

Empathic communication skills help motivate understanding of safety, significance of harms, impact on succeeding generations, and social consequences.

Physicians should provide women considering abortion after Down syndrome screening with unbiased information and not attempt to influence their decision.

A guardian’s request to sterilize a woman with intellectual disabilities is not ethically justifiable unless the woman assents and it is to her benefit.

Clinical applications of AI prompt consideration of how responsibility should be distributed among professionals, tech companies, and others.

Applications can identify and monitor patients. They can also diagnose genetic, medical, and behavioral conditions.

Limited understanding of disease etiology often leads to resistance, which can result in low vaccine uptake.

Noninvasive prenatal testing arguably constitutes a form of eugenics in a social context in which certain reproductive outcomes are not valued.