Perhaps machine learning systems trained on patients’ electronic health records and social media footprints could be used as decision aids when patients lack capacity or face overwhelming decisions.

End-stage heart failure patients can experience depression along with their chronic illness. Multidisciplinary responses are critical.

In art, authenticity tends to be perceived in proximity to an artist’s original intention, and it can help guide future research in germline editing.

Empathic communication skills help motivate understanding of safety, significance of harms, impact on succeeding generations, and social consequences.

Transnational monitoring efforts should focus on safety, defining standard of care, and promoting just access to innovation.

Clinically and ethically relevant questions are related to patient safety, therapeutic efficacy, equitable access, and global governance over humanity’s genetic legacy.

Gene editing reminds professionals and the public that this technology’s reach goes beyond treating somatic disease to germline consequences yet unknown.

International debate about human genome editing governance has undergone a paradigm shift and suggests that inclusive public deliberation is still important.

This image aims to promote reflection about patients’ feelings of sadness, despair, helplessness, and uncertainty upon being diagnosed.

The DSM-5 Task Force’s handling of the ethical controversy over the bereavement exclusion demonstrates the need for more inclusive deliberative processes.