The Declaration of Helsinki was recently revised to require that the control arm of a trial use the current standard of care, even if that standard is not generally available in developing nations where the research is being conducted.
Those conducting Western-style clinical trial research in developing countries must consider the manner in which ethical principals are implemented within local standards of care.
The AMA's Code of Medical Ethics' opinion on the use of databanks in genomic research requires informed consent by groups and individuals who are subjects of research.