AMA Journal of Ethics^®

Systematic analysis of extant research ethics guidance is needed for conflict-affected countries and UN agencies.

IRBs must report human subject research protocol deviations and university leadership might also need to motivate compliance with federal regulations.

African cancer research is embedded in underresourced health care infrastructures, illuminating ethical questions about benefit sharing and governance.

Questions about data privacy need to be addressed when research institutions negotiate with companies developing mobile health applications. Commercial terms of use and data sharing notifications should be reviewed before use in human subject research settings.

Emergency research that requires exception from informed consent presents challenges in defining and reaching the at-risk community.

Community-based participatory research ensures that community protections, risks, and benefits are considered during ethical reviews of research protocols.

The AMA Code of Medical Ethics opinions related to international health and research.

This month, AMA Journal of Ethics theme editor Cynthia Tsay, MPhil, a second-year medical student at the Yale School of Medicine, interviewed Robert Levine, MD, about changes in clinical research guidelines, problems with IRB documentation, and the top ethical challenges facing clinical researchers today.

The 2015 proposed changes to the Common Rule for human subjects research protections, which are a response to novel methods of data collection and analysis, clarify and broaden the scope of informed consent processes, identify exemptions, and make changes to Institutional Review Board requirements.