Current research suggests that the most effective treatment for pediatric depression is a combination of cognitive behavioral therapy and antidepressant medication, but continued funding for independent research is necessary.

Several recent court cases illustrate how some states are attempting to mandate physician reporting of all underage sexual activity as instances of child abuse.

Physicians should honor confidentiality whenever possible when screening and treating adolescents for sensitive health conditions such as substance abuse.

Physicians should not perform involuntary drug testing on an adolescent with decisional capacity without strong medical or legal reasons, even if the parents request the test.

The theme editor introduces a special issue focusing on quality of life and clinical decision making.

The proliferation of enhancement technologies and pharmacological agents has perpetuated the view of American doctors and patients of medical care as a market commodity driven by what consumers want and are willing to pay for.

Two physicians offer commentaries about the use of prenatal predictive testing for a late-onset disease like Huntington's and question whether the pregnant woman should ultimately have the decisional autonomy to determine the quality of life of the unborn child.

Two medical technology researchers argue that patients' own valuations of their health states may result in devaluation of interventions that can help them.

Physicians should ensure that overwhelmed young patients receive the psychological support they need, especially when recommending optional treatments following the grueling main treatment for breast cancer.

Quality-of-life questionnaires can help evaluate the success of treatment for patients with lumbar sciatica.