Rachel A. Mills, MS, Susanne B. Haga, PhD, and Geoffrey S. Ginsburg, MD, PhD
Clinical utility is a test’s contribution to health outcomes, while personal utility considers the psychosocial and lifestyle effects and the value of the information to the patient.
Chromosomal microarray analysis reveals many gene variants of unknown significance. The uncertainty about these variants—might they be deleterious or are they benign?—complicates genetic counseling.
Equating conscience with clinical judgment challenges the way that ethics is marginalized in medical education. Ethics is simply an account of what good medical practice looks like in particular situations.
Ruth M. Farrell, MD, MA, Holly Pederson, MD, and Shilpa Padia, MD
Though they claim to, direct-to-consumer genetic tests may not correctly identify an individual's ancestral background, and thus may overstate or understate one's risk for heritable disease.
The American College of Physicians and the Federation of State Medical Boards’ guidelines for online medical professionalism apply existing norms of communication and confidentiality to new settings but will need to be modified in light of technological advances and unanswered questions.
AMA J Ethics. 2015;17(5):441-447. doi:
10.1001/journalofethics.2015.17.5.nlit1-1505.
In Association for Molecular Pathology v. Myriad Genetics, Inc., the Supreme Court ruled that synthetically created DNA is patentable, but the isolation of unaltered gene sequences is not.
AMA J Ethics. 2015;17(9):849-853. doi:
10.1001/journalofethics.2015.17.9.hlaw1-1509.