Chromosomal microarray analysis reveals many gene variants of unknown significance. The uncertainty about these variants—might they be deleterious or are they benign?—complicates genetic counseling.
Ruth M. Farrell, MD, MA, Holly Pederson, MD, and Shilpa Padia, MD
Though they claim to, direct-to-consumer genetic tests may not correctly identify an individual's ancestral background, and thus may overstate or understate one's risk for heritable disease.
J. Brian Szender, MD, MS and Shashikant B. Lele, MD
The estimated reduction in risk of ovarian cancer for any woman undergoing opportunistic removal of the Fallopian tubes is up to 50 percent, but whether removal is more beneficial than ligation has not been established.
AMA J Ethics. 2015; 17(9):843-848. doi:
10.1001/journalofethics.2015.17.9.stas1-1509.
The AMA Code of Medical Ethics' opinions on confidential care for sexually active minors and physicians' exercise of conscience in refusal of services.
A medical student’s desire to practice the specialty that he or she finds most interesting should not outweigh the right of patients in a pluralistic society to receive a full range of legal medical services.
There is a market for direct-to-consumer genetic testing and a need for better consumer information and more regulation of tests and testing laboratories.
U.S. and international medical organizations recommend against testing children for genetic diseases that occur after adolescence and for which no prevention or treatment is available.