Transgender people planning a medical transition face decisions about family planning, fertility preservation, and how to access gender-affirming treatment.

Physicians should extend gender-affirming treatment to gender-nonconforming people, who experience discrimination and health disparities.

Private equity firms exacerbate health inequity by driving hospital closures in historically underserved communities. Now nonprofit health systems are also vulnerable.

Poor-quality antimicrobial medicines continue to proliferate across supply chains, threatening patients’ health and safety, especially in low- and middle-income regions.

Reconsider regulatory and clinical frameworks for prescribing long-term opioid therapy for pain and prescribing opioids to treat OUD.

Equity requires full access to evidence-based OUD care, housing stability, and education and employment opportunities.

MLP innovations seek to address patients’ criminal as well as postrelease civil legal needs.

Five lessons from the patient-centered medical home could help motivate infrastructure investment, care innovation, and payment reforms critical to achieving equity.

Statutory limitations prevent the FDA from effectively regulating dietary supplements and have generated numerous calls for reform.

Illegal, fraudulent, adulterated, or improperly labeled products should be regarded as sources of possible clinical and ethical harm to patients.