When patients are unable to express their wishes and do not have surrogates or advance directives, which and whose values should inform decision making for them? We discuss ethical complexities of caring for unrepresented patients.

Dr Laura Guidry-Grimes helps us consider whether and which decisions can be shared with people experiencing mental illnesses.

Dania Pagarkar joins Ethics Talk to discuss her article, coauthored with Drs Erin Harrop and Lisa Erlanger: “How Should We Approach Body Size Diversity in Clinical Trials?”

Ari Ne’eman joins Ethics Talk to discuss his article, When Disability is Defined by Behavior, Outcome Measures Should Not promote “Passing”.

Dr Dónal O’Mathúna joins Ethics Talk to discuss his article, coauthored with Dr Nawaraj Upadhaya: “Should Children Be Enrolled in Clinical Research in Conflict Zones?”

AMA Journal of Ethics theme editor Emily Johnson, a fourth-year medical student at the University of Colorado School of Medicine, interviewed Susan Mizner, JD, about some merits, drawbacks, and alternatives to guardianship.

Dr James Downs joins Ethics Talk to discuss the underrecognized contributions of marginalized peoples to the origins of epidemiology, and Dr Rae Anne Martinez outlines good uses of race and ethnicity data in epidemiological research.

Dr Shelli L. Feder joins Ethics Talk to discuss her article, coauthored with Dr Kathleen M. Akgün: “Whom Should We Regard as Responsible for Health Record Inaccuracies That Hinder Population-Based Fact Finding?”

Dr Douglas Shenson joins Ethics Talk to discuss his article, coauthored with Dr Beverley J. Sheares and Chelesa Fearce: “What Should Health Professions Students Learn About Data Bias?”