When patients are unable to express their wishes and do not have surrogates or advance directives, which and whose values should inform decision making for them? We discuss ethical complexities of caring for unrepresented patients.

Dr Travis Rieder discusses his own experiences with opioids and the ethical challenges of “legacy patients,” and Dr Stephanie Zaza, president of the American College of Preventive Medicine, discusses the future of opioid research priorities.

Kim Christiansen discusses her experiences managing limited mobility and chronic pain from a partial spinal cord injury and Dr Natalie Hoff describes good physical therapy care for patients with chronic migraine headaches.

Dr Liam G. McCoy joins Ethics Talk to discuss his article, coauthored with Drs Zainab Doleeb, Jazleen Dada, and Catherine Allaire: “Underrecognition of Dysmenorrhea Is an Iatrogenic Harm.”

AMA Journal of Ethics theme editor Amanda Xi, MD, a transitional year resident at Henry Ford Hospital, interviewed Donald M. Berwick, MD, shortly before the Supreme Court’s decision in King versus Burwell.

Virtual Mentor issue editor Sophia Cedola, a medical student at Columbia University College of Physicians and Surgeons, interviewed Dr. Craig Blinderman about talking with patients who are terminally ill, asking him whether there are some key “do’s” and “don’ts” for having end-of-life conversations with patients and their families.

This month, Virtual Mentor spoke with Dr. Alex Ding and Mr. Jordan VanLare, a fourth-year medical student at Columbia University College of Physicians and Surgeons, about their impressions of health reform and how it will impact the medical practice environment they will soon enter.

Dr Thaddeus M. Pope joins Health By Law to discuss updates to the Uniform Law Commission’s Health-Care Decisions Act.

Dr Noah Boton joins Ethics Talk to discuss his article, coauthored with Dr Jeffrey Larnard: “When Should Patients at the End of Life Get Antimicrobials?”

Dr Katherin M. Duthie joins Ethics Talk to discuss her article, coauthored with Dr Kathryn A. Dong: “How Should Risks and Benefits of Short-Acting Opioids Be Evaluated in the Care of Inpatients With OUD?”