Clinical Research Ethics

Twentieth-century human subject research protections developed as pointed responses to well-documented human rights abuses, such as those revealed in the Nuremburg Trials and those that occurred in the US Public Health Service Syphilis Study at Tuskegee. Today, clinical research ethics has expanded beyond the need to secure informed consent from potential human subjects to incorporating the input of subjects and their communities into planning, implementing, and sharing results of research. The December 2015 issue of the AMA Journal of Ethics interprets lessons from important historical moments in our past and also suggests how key ideas, such as open data sharing, command our current consideration and help broaden the nature and scope of future research ethics questions and dilemmas.

Volume 17, Number 12: 1103-1196 Full Issue PDF